Article
Specific changes in the proteomic pattern produced by the BRCA1-Ser1841Asn missense mutation.
The international journal of biochemistry & cell biology - 1 Jan 2007
Crugliano Telma, Quaresima Barbara, Gaspari Marco, Faniello Maria Concetta, Romeo Francesco, Baudi Francesco, Cuda Giovanni, Costanzo Francesco, Venuta Salvatore
Abstract excerpt
BRCA1 is a nuclear phosphoprotein that plays a key role in many cell functions, including DNA repair, control of transcription, recombination and cell cycle homeostasis. Inherited missense mutations in the BRCA1 gene may predispose to breast and ovarian cancer, but the molecular mechanisms underlying BRCA1-induced tumorigenesis are still to be elucidated. Functional studies performed so far have contributed to...
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