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Article

Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice.

The Journal of physiology - 15 Aug 2012

Lu Mei-Hong, Takemoto Makoto, Watanabe Ken, Luo Huan, Nishimura Masataka, Yano Masato, Tomimoto Hidekazu, Okazaki Toshiro, Oike Yuichi, Song Wen-Jie

Abstract excerpt

Sphingomyelin (SM) is a sphingolipid reported to function as a structural component of plasma membranes and to participate in signal transduction. The role of SM metabolism in the process of hearing remains controversial. Here, we examined the role of SM synthase (SMS), which is subcategorized into the family members SMS1 and SMS2, in auditory function. Measurements of auditory brainstem response (ABR) revealed...

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Share to Gene Expression Regulation, Enzymologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Transferases (Other Substituted Phosphate Groups)

Source

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Identifiers

PMID: 22641779
DOI: 10.1113/jphysiol.2012.235846
PMCID: PMC3476646

Genes

KCNQ1
ABR
SMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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