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Article

Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model.

BMC medicine - 22 Dec 2006

Jabba Sairam V, Oelke Alisha, Singh Ruchira, Maganti Rajanikanth J, Fleming Sherry, Wall Susan M, Everett Lorraine A, Green Eric D, Wangemann Philine

Abstract excerpt

BACKGROUND: Pendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pendrin expression and deafness using mice that have (Slc26a4+/+ or Slc26a4+/-) or lack (Slc26a4-/-) a complete Slc26a4 gene. Previously, we reported that stria vascularis of adult Slc26a4-/-...

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Identifiers

PMID: 17187680
DOI: 10.1186/1741-7015-4-37
PMCID: PMC1796619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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