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Article

Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells

24 May 2012

Abstract excerpt

The cancer stem cell (CSC) is responsible for the initiation, proliferation and radiation resistance. Side population (SP) cells are a rare subset of cells enriched with CSCs. The targeting of key signaling pathways that are active in CSCs is a therapeutic approach to treating cancer. Notch signaling is important for the self-renewal and maintenance of stem cells. Our previous studies demonstrated that...

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PMID: 22641197
DOI: 10.3892/or.2012.1830

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