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Stem-like Cancer Cells Are Inducible by Increasing Genomic Instability in Cancer Cells

10 Dec 2009

Abstract excerpt

The existence of cancer stem cells (CSCs) or stem-like cancer cells (SLCCs) is regarded as the cause of tumor formation and recurrence. However, the origin of such cells remains controversial with two competing hypotheses: CSCs are either transformed from tissue adult stem cells or dedifferentiated from transformed progenitor cells. Compelling evidence has determined the chromosomal aneuploidy to be one of the...

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PMID: 20007324
DOI: 10.1074/jbc.m109.048397

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