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Article

The balance between two isoforms of LEF-1 regulates colon carcinoma growth.

BMC gastroenterology - 28 May 2012

Wang Shu-Hong, Nan Ke-Jun, Wang Yao-Chun, Wang Wen-Juan, Tian Tao

Abstract excerpt

BACKGROUND: Colon cancer is one of the most aggressive human malignancies, with a very poor prognosis. Although it has been suggested that different isoforms of the lymphoid enhancer factor (LEF-1) have opposing biological activities, the biological outcome of aberrant LEF-1 activation in colon cancer is still unclear. The aim of this study was to evaluate the effect of the different LEF-1 phenotypes on the...

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Identifiers

PMID: 22639890
DOI: 10.1186/1471-230X-12-53
PMCID: PMC3407021

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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