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Article

Evidence of cis-acting regulatory variation in PTPN22 in patients with rheumatoid arthritis.

Scandinavian journal of rheumatology - 1 Aug 2012

Harrison P, Southam L, Chapman K, Locklin R, Sabokbar A, Wordsworth B P, Pointon J J

Abstract excerpt

OBJECTIVES: To assess whether there are cis-regulatory polymorphisms that regulate protein tyrosine phosphatase, non-receptor type 22 (PTPN22) expression in rheumatoid arthritis (RA). METHODS: RNA was extracted from positively selected CD56+, CD8+, and CD4+ mononuclear cells and the 'residual' cells from 12 RA patients heterozygous for the PTPN22 C1858T single nucleotide polymorphism (SNP) (rs2476601). Relative...

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Source

Identifiers

PMID: 22632125
DOI: 10.3109/03009742.2012.658859

Genes

PTPN22

Variants

rs2476601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence of cis-acting regulatory variation in PTPN22 in patients with rheumatoid arthritis.PMID 22632125Read ↗

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