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Article

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.

Nature genetics - 31 Jul 2011

Hirota Tomomitsu, Takahashi Atsushi, Kubo Michiaki, Tsunoda Tatsuhiko, Tomita Kaori, Doi Satoru, Fujita Kimie, Miyatake Akihiko, Enomoto Tadao, Miyagawa Takehiko, Adachi Mitsuru, Tanaka Hiroshi, Niimi Akio, Matsumoto Hisako, Ito Isao, Masuko Hironori, Sakamoto Tohru, Hizawa Nobuyuki, Taniguchi Masami, Lima John J, Irvin Charles G, Peters Stephen P, Himes Blanca E, Litonjua Augusto A, Tantisira Kelan G, Weiss Scott T, Kamatani Naoyuki, Nakamura Yusuke, Tamari Mayumi

Abstract excerpt

Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility...

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Identifiers

PMID: 21804548
DOI: 10.1038/ng.887
PMCID: PMC4310726

Genes

FEV
GAB1
TSLP
USP38

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