Article
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.
PloS one - 1 Jan 2012
Agustí Alvar, Edwards Lisa D, Rennard Stephen I, MacNee William, Tal-Singer Ruth, Miller Bruce E, Vestbo Jørgen, Lomas David A, Calverley Peter M A, Wouters Emiel, Crim Courtney, Yates Julie C, Silverman Edwin K, Coxson Harvey O, Bakke Per, Mayer Ruth J, Celli Bartolome
Abstract excerpt
BACKGROUND: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552). METHODS AND FINDINGS: Six...
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