Article
Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 May 2012
Park Jee-Young, Ikeda Hiromi, Ikenaga Takanori, Ono Fumihito
Abstract excerpt
The accumulation of acetylcholine receptors (AChRs) at nerve terminals is critical for signal transmission at the neuromuscular junction, and rapsyn is essential for this process. Previous studies suggest that AChRs might direct rapsyn self-clusters to the synapse. In vivo experiments with fluorescently tagged AChR or rapsyn in zebrafish larvae revealed that rapsyn self-clusters separate from AChRs did not exist...
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