Rapsyn and agrin slow the metabolic degradation of the acetylcholine receptor.

doi:10.1006/mcne.1997.0634

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Article

Rapsyn and agrin slow the metabolic degradation of the acetylcholine receptor.

Molecular and cellular neurosciences - 1 Jan 1997

Phillips W D, Vladeta D, Han H, Noakes P G

Abstract excerpt

Rapsyn is a 43-kDa cytoplasmic protein that clusters nicotinic acetylcholine receptors (AChR) in the postsynaptic membrane. Here we examine the effect of rapsynmediated AChR clustering on the metabolic stability of the AChR. When transfected into QT-6 fibroblasts, cell surface AChRs (alpha, beta,...

Topics

Agrin
Animals
Antibodies
CHO Cells
Cell Line
Cricetinae
Fibroblasts
Fluorescent Antibody Technique
Muscle Proteins
Muscles
Mutation
Receptor Aggregation
Receptors, Cholinergic
Receptors, Nicotinic

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