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Article

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs.

Aging cell - 1 Aug 2012

Talens Rudolf P, Christensen Kaare, Putter Hein, Willemsen Gonneke, Christiansen Lene, Kremer Dennis, Suchiman H Eka D, Slagboom P Eline, Boomsma Dorret I, Heijmans Bastiaan T

Abstract excerpt

The accumulation of epigenetic changes was proposed to contribute to the age-related increase in the risk of most common diseases. In this study on 230 monozygotic twin pairs (MZ pairs), aged 18-89 years, we investigated the occurrence of epigenetic changes over the adult lifespan. Using mass spectrometry, we investigated variation in global (LINE1) DNA methylation and in DNA methylation at INS, KCNQ1OT1, IGF2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22621408
DOI: 10.1111/j.1474-9726.2012.00835.x
PMCID: PMC3399918

Genes

CRH
ABCA1
INS
LEP
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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