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Article

The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype.

British journal of clinical pharmacology - 1 Jan 2013

Maddison John, Somogyi Andrew A, Jensen Berit P, James Heather M, Gentgall Melanie, Rolan Paul E

Abstract excerpt

AIMS: 1) To determine the pharmacokinetics and pharmacodynamics of (R)- and (S)-warfarin given alone and in combination and 2) to determine whether the relative potency of (R)- and (S)-warfarin is dependent on VKORC1 genotype. METHODS: A three way crossover study was conducted in which 17 healthy...

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Identifiers

PMID: 22616655
DOI: 10.1111/j.1365-2125.2012.04335.x
PMCID: PMC3555060

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22616655-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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