Article
Arabidopsis RPT2a, 19S proteasome subunit, regulates gene silencing via DNA methylation.
PloS one - 1 Jan 2012
Sako Kaori, Maki Yuko, Kanai Tomoyuki, Kato Eriko, Maekawa Shugo, Yasuda Shigetaka, Sato Takeo, Watahiki Masaaki K, Yamaguchi Junji
Abstract excerpt
The ubiquitin/proteasome pathway plays a crucial role in many biological processes. Here we report a novel role for the Arabidopsis 19S proteasome subunit RPT2a in regulating gene activity at the transcriptional level via DNA methylation. Knockout mutation of the RPT2a gene did not alter global protein levels; however, the transcriptional activities of reporter transgenes were severely reduced compared to those...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.