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Article

Epigenetic transgenerational inheritance of altered stress responses.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2012

Crews David, Gillette Ross, Scarpino Samuel V, Manikkam Mohan, Savenkova Marina I, Skinner Michael K

Abstract excerpt

Ancestral environmental exposures have previously been shown to promote epigenetic transgenerational inheritance and influence all aspects of an individual's life history. In addition, proximate life events such as chronic stress have documented effects on the development of physiological, neural, and behavioral phenotypes in adulthood. We used a systems biology approach to investigate in male rats the...

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Identifiers

PMID: 22615374
DOI: 10.1073/pnas.1118514109
PMCID: PMC3384163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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