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Article

Mutations in the GABAA receptor that mimic the allosteric ligand etomidate.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Forman Stuart A, Stewart Deirdre

Abstract excerpt

Etomidate is a hydrophobic molecule, a potent general anesthetic, and the best understood drug in this group. Etomidate's target molecules are GABA(A) receptors, its site of action has been identified with photolabeling, and a quantitative allosteric coagonist model has emerged for etomidate effects on GABA(A) receptors. We have shown that when methionine residues that are thought to be adjacent to the etomidate...

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Identifiers

PMID: 22052498
DOI: 10.1007/978-1-61779-334-9_17
PMCID: PMC3360466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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