Serial cloning of pigs by somatic cell nuclear transfer: restoration of phenotypic normality during serial cloning.

doi:10.1002/dvdy.21308

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Article

Serial cloning of pigs by somatic cell nuclear transfer: restoration of phenotypic normality during serial cloning.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2007

Cho Seong-Keun, Kim Jae-Hwan, Park Jong-Yi, Choi Yun-Jung, Bang Jae-Il, Hwang Kyu-Chan, Cho Eun-Jeong, Sohn Sea-Hwan, Uhm Sang Jun, Koo Deog-Bon, Lee Kyung-Kwang, Kim Teoan, Kim Jin-Hoi

Abstract excerpt

Somatic cell nuclear transfer (scNT) is a useful way to create cloned animals. However, scNT clones exhibit high levels of phenotypic instability. This instability may be due to epigenetic reprogramming and/or genomic damage in the donor cells. To test this, we produced transgenic pig fibroblasts harboring the truncated human thrombopoietin (hTPO) gene and used them as donor cells in scNT to produce...

Topics

Animals
Animals, Genetically Modified
Base Sequence
Cloning, Organism
DNA Damage
DNA Primers
Female
Genomic Instability
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Nuclear Transfer Techniques

Phenotype

Placenta

Pregnancy

Promoter Regions, Genetic

Recombinant Proteins

Sus scrofa

Source

Open in PubMed

Identifiers

PMID: 17849457
DOI: 10.1002/dvdy.21308

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