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Article

Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis.

The Journal of biological chemistry - 6 Jul 2012

DiTacchio Luciano, Bowles Josephine, Shin Sook, Lim Dae-Sik, Koopman Peter, Janknecht Ralf

Abstract excerpt

ER71, also known as ETV2, is an ETS transcription factor that is expressed during embryogenesis and in adult testes. We show that Er71 transcription can be up-regulated by SRY, the key determinant of male differentiation. Accordingly, SRY bound to and activated the Er71 promoter, and mutation of a putative SRY binding site abolished this promoter activation. In turn, ER71 was able to bind to the promoter of Sox9,...

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Topics

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Share to Embryo, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to RNA Interference

Share to Sertoli Cells

Share to Sex-Determining Region Y Protein

Share to SOX9 Transcription Factor

Share to Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 22613723
DOI: 10.1074/jbc.M111.320101
PMCID: PMC3390640

Genes

SRY
SOX9
ETV2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis.PMID 22613723Read ↗

SOX9 and SRY binding sites on mouse mXYSRa/Enh13 enhancer redundantly regulate Sox9 expression to varying degreesSemantic proximity Read ↗

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SOX9 regulates expression of the male fertility gene Ets variant factor 5 (ETV5) during mammalian sex developmentSemantic proximity Read ↗

A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development.Semantic proximity Read ↗

The Sex-Determining Factors SRY and SOX9 Regulate Similar Target Genes and Promote Testis Cord Formation during Testicular DifferentiationSemantic proximity Read ↗

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Basic Helix-Loop-Helix Transcription Factor TCF21 Is a Downstream Target of the Male Sex Determining Gene SRYSemantic proximity Read ↗

The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9]Semantic proximity Read ↗

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