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Article

Using ortholog sequence data to predict the functional relevance of mutations in G-protein-coupled receptors.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2012

Cöster Maxi, Wittkopf Doreen, Kreuchwig Annika, Kleinau Gunnar, Thor Doreen, Krause Gerd, Schöneberg Torsten

Abstract excerpt

Evaluating the functional relevance of naturally occurring gene variants usually requires experimental testing or is even impossible because of the lack of appropriate functional assays. Here we have analyzed whether comparative sequence data from orthologs are suitable to predict the functional relevance of mutations in a model protein, a G-protein-coupled receptor for ADP (P2Y(12)). The functional effect of...

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Identifiers

PMID: 22611087
DOI: 10.1096/fj.12-203737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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