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Article

The intercellular adhesion molecule-1 (ICAM-1) gene polymorphism K469E in end-stage renal disease patients with cardiovascular disease.

Human immunology - 1 Aug 2012

Buraczynska Monika, Zaluska Wojciech, Baranowicz-Gaszczyk Iwona, Buraczynska Kinga, Niemczyk Ewa, Ksiazek Andrzej

Abstract excerpt

The intercellular adhesion molecule-1 (ICAM-1) mediates interaction of activated endothelial cells with leukocytes. It plays an important role in the pathogenesis of atherosclerosis. A functionally important polymorphism of the ICAM-1 gene, K469E, has been described. We investigated whether this polymorphism influences the risk of CVD in end-stage renal disease (ESRD) patients. The groups of 1016 ESRD patients...

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PMID: 22609477
DOI: 10.1016/j.humimm.2012.05.007

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