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FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer

11 Apr 2024

Abstract excerpt

FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering transcription factors that build gene expression capacity and play a central role in biological processes, including organogenesis and differentiation, glycolipid metabolism, proliferation, migration and invasion, and drug resistance. Notably, FOXA1 and FOXA2 may exert antagonistic, synergistic, or complementary effects in the aforementioned...

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PMID: 38605023
DOI: 10.1038/s41420-024-01936-1

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