Article
The prevalence of hepatitis B virus surface antigen (HBsAg) variations and correlation with the clinical and serologic pictures in chronic carriers from Khorasan Province, North-East of Iran.
Acta medica Iranica - 1 Jan 2012
Ghaziasadi Azam, Ziaee Masoud, Norouzi Mehdi, Malekzadeh Reza, Alavian Seyed Moayed, Saberfar Esmaeil, Judaki Mohammad Ali, Ghamari Shiva, Khedive Abolfazl, Namazi Alireza, Rahimnia Ramin, Jazayeri Seyed Mohammad
Abstract excerpt
This study was designed to determine the correlation of hepatitis B virus surface Ag (HBsAg) variations with the clinical/serological pictures among chronic HBsAg positive patients. The surface gene (S-gene) was amplified and directly sequenced in twenty-five patients. Eight samples (group I) contained at least one mutation at the amino acid level. Five showed alanine aminotransferase (ALT) levels above the...
Topics
- Adult
- Alanine Transaminase
- Amino Acid Sequence
- Biomarkers
- Chi-Square Distribution
- Female
- Genotype
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Iran