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Article

Pseudomonas aeruginosa exopolysaccharide Psl promotes resistance to the biofilm inhibitor polysorbate 80.

Antimicrobial agents and chemotherapy - 1 Aug 2012

Zegans Michael E, Wozniak Daniel, Griffin Edward, Toutain-Kidd Christine M, Hammond John H, Garfoot Andrew, Lam Joseph S

Abstract excerpt

Polysorbate 80 (PS80) is a nonionic surfactant and detergent that inhibits biofilm formation by Pseudomonas aeruginosa at concentrations as low as 0.001% and is well tolerated in human tissues. However, certain clinical and laboratory strains (PAO1) of P. aeruginosa are able to form biofilms in the presence of PS80. To better understand this resistance, we performed transposon mutagenesis with a PS80-resistant...

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Identifiers

PMID: 22585230
DOI: 10.1128/AAC.00373-12
PMCID: PMC3421584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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