Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota

11 May 2012

Abstract excerpt

The virulence mechanisms that allow pathogens to colonize the intestine remain unclear. Here, we show that germ-free animals are unable to eradicate Citrobacter rodentium, a model for human infections with attaching and effacing bacteria. Early in infection, virulence genes were expressed and required for pathogen growth in conventionally raised mice but not germ-free mice. Virulence gene expression was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clostridium difficile and Clostridium perfringens research
Share to Escherichia coli research studies
Share to Gut microbiota and health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22582016
DOI: 10.1126/science.1222195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut MicrobiotaPMID 22582016Read ↗

Intimate Adhesion Is Essential for the Pathogen-Specific Inflammatory and Immune Responses in the Gut of Mice Infected with Citrobacter rodentium.Semantic proximity Read ↗

Systematic Analysis of Two-Component Systems in Citrobacter rodentium Reveals Positive and Negative Roles in Virulence.Semantic proximity Read ↗

Investigation of Host and Pathogen Contributions to Infectious Colitis Using the Citrobacter rodentium Mouse Model of Infection.Semantic proximity Read ↗

Helicobacter spp. are prevalent in wild mice and protect from lethal Citrobacter rodentium infection in the absence of adaptive immunitySemantic proximity Read ↗

Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogenSemantic proximity Read ↗

A novel C57BL/6 mouse model for the study of severe <i>Citrobacter rodentium</i> infectionSemantic proximity Read ↗

Quorum sensing has an unexpected role in virulence in the model pathogen Citrobacter rodentium.Semantic proximity Read ↗

Central Role for B Lymphocytes and CD4 <sup>+</sup> T Cells in Immunity to Infection by the Attaching and Effacing Pathogen <i>Citrobacter rodentium</i>Semantic proximity Read ↗

Mouse models for bacterial enteropathogen infections: insights into the role of colonization resistanceSemantic proximity Read ↗

Vancomycin promotes key microbiota-pathogen interactions and removes protective bottlenecks to enteric infectionSemantic proximity Read ↗

Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE.Semantic proximity Read ↗

Identification and characterization of Cri1, a locus controlling mortality during Citrobacter rodentium infection in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.