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Article

Systematic Analysis of Two-Component Systems in Citrobacter rodentium Reveals Positive and Negative Roles in Virulence.

Infection and immunity - 1 Feb 2017

Thomassin Jenny-Lee, Leclerc Jean-Mathieu, Giannakopoulou Natalia, Zhu Lei, Salmon Kristiana, Portt Andrea, Daigle France, Le Moual Hervé, Gruenheid Samantha

Abstract excerpt

Citrobacter rodentium is a murine pathogen used to model intestinal infections caused by the human diarrheal pathogens enterohemorrhagic and enteropathogenic Escherichia coli During infection, bacteria use two-component systems (TCSs) to detect changing environmental cues within the host, allowing for rapid adaptation by altering the expression of specific genes. In this study, 26 TCSs were identified in C....

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Identifiers

PMID: 27872242
DOI: 10.1128/IAI.00654-16
PMCID: PMC5278178

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