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Article

An apoptosis‐related gene network induced by novel compound‐cRGD in human breast cancer cells

3 Jul 2007

Abstract excerpt

Synthetic peptides with the arginine-glycine-aspartate (RGD) motif have been used widely as inhibitors of integrin-ligand interactions to study cell growth, adhesion, migration and differentiation. We designed cyclic-RGD peptide (Tpa-RGDWPC-, cRGD) which could cause cell death in MCF-7 cell line. In order to understand the mechanism involved in cRGD-induced apoptosis, we used microarray, real-time quantitative...

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Identifiers

PMID: 17624335
DOI: 10.1016/j.febslet.2007.06.067

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