Article
Reversal of the malignant phenotype of cervical cancer CaSki cells through adeno-associated virus-mediated delivery of HPV16 E7 antisense RNA.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2006
Wu Sufang, Meng Li, Wang Shixuan, Wang Wei, Xi Ling, Tian Xun, Chen Gang, Wu Ying, Zhou Jianfeng, Xu Gang, Lu Yunping, Ma Ding
Abstract excerpt
Human papillomavirus (HPV) infection is the most important risk factor for the development of cervical cancer. The oncogene E7 from high-risk HPV strains has the ability to immortalize epithelial cells and increase cellular transformation in culture. In this study, we explored the possibility of preventing cervical cancer growth by inhibiting HPV16 E7 expression through gene transfer of an antisense construct. A...
Topics
- Animals
- Apoptosis
- Carcinogenicity Tests
- Carcinoma, Squamous Cell
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Disease Models, Animal
- Down-Regulation
- Female