Article
Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis.
Development (Cambridge, England) - 1 Jun 2012
Sasakura Yasunori, Kanda Miyuki, Ikeda Taku, Horie Takeo, Kawai Narudo, Ogura Yosuke, Yoshida Reiko, Hozumi Akiko, Satoh Nori, Fujiwara Shigeki
Abstract excerpt
Retinoic acid (RA)-mediated expression of the homeobox gene Hox1 is a hallmark of the chordate central nervous system (CNS). It has been suggested that the RA-Hox1 network also functions in the epidermal ectoderm of chordates. Here, we show that in the urochordate ascidian Ciona intestinalis, RA-Hox1 in the epidermal ectoderm is necessary for formation of the atrial siphon placode (ASP), a structure homologous to...
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