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Article

Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain.

Molecular pharmacology - 1 Aug 2012

Ushijima Kentarou, Koyanagi Satoru, Sato Yuuki, Ogata Takamitsu, Matsunaga Naoya, Fujimura Akio, Ohdo Shigehiro

Abstract excerpt

Serotonin (5-HT) transporter (5-HTT) plays a key role in the control of 5-HT neuronal activity by reuptaking extracellular 5-HT from the synapse cleft. We have previously demonstrated that 5-HTT mRNA expression levels and its uptake activity in the mouse midbrain are significantly higher in the dark phase than those in the light phase. However, the molecular mechanisms of time-dependent expression of 5-HTT have...

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Source

Identifiers

PMID: 22572884
DOI: 10.1124/mol.112.079079

Genes

HTT
ATF4
BMAL1
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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