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Article

Ectopic ERK expression induces phenotypic conversion of C10 cells and alters DNA methyltransferase expression.

BMC research notes - 4 May 2012

Sontag Ryan L, Weber Thomas J

Abstract excerpt

BACKGROUND: Many lung carcinogens activate mitogen activated protein kinase (MAPK) pathways and DNA methyltransferases (DNMTs) are under investigation as therapeutic targets for lung cancer. Our goal is to determine whether C10 type II alveolar epithelial cells are a sensitive model to investigate ERK-dependent transformation and DNMT expression patterns in experimental lung cancer. FINDINGS: Ectopic expression...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22559742
DOI: 10.1186/1756-0500-5-217
PMCID: PMC3416577

Genes

DNMT1
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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