Article
Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition.
International journal of oncology - 1 Jul 2012
Ouelaa-Benslama Radia, De Wever Olivier, Hendrix An, Sabbah Michèle, Lambein Kathleen, Land David, Prévost Grégoire, Bracke Marc, Hung Mien-Chie, Larsen Annette K, Emami Shahin, Gespach Christian
Abstract excerpt
The epithelial-to-mesenchymal transition (EMT) confers an aggressive subtype associated with chemotherapy resistance in epithelial cancers. However, the mechanisms underlying the EMT and its associated signaling dysfunctions are still poorly understood. In two genetic models of MCF-7 breast cance...
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