Article
Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses.
Bioorganic & medicinal chemistry letters - 1 Jun 2012
Dao Trong Tuan, Dang Thai Trung, Nguyen Phi Hung, Kim Eunhee, Thuong Phuong Thien, Oh Won Keun
Abstract excerpt
The emergence of the H1N1 swine flu pandemic has the possibility to develop the occurrence of disaster- or drug-resistant viruses by additional reassortments in novel influenza A virus. In the course of an anti-influenza screening program for natural products, 10 xanthone derivatives (1-10) were isolated by bioassay-guided fractionation from the EtOAc-soluble extract of Polygala karensium. Compounds 1, 3, 5, 7,...
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