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Article

Dramatic effect of levetiracetam in early-onset epileptic encephalopathy due to STXBP1 mutation.

Brain & development - 1 Jan 2016

Dilena Robertino, Striano Pasquale, Traverso Monica, Viri Maurizio, Cristofori Gloria, Tadini Laura, Barbieri Sergio, Romeo Antonino, Zara Federico

Abstract excerpt

BACKGROUND: Syntaxin Binding Protein 1 (STXBP1) mutations determine a central neurotransmission dysfunction through impairment of the synaptic vesicle release, thus causing a spectrum of phenotypes varying from syndromic and non-syndromic epilepsy to intellectual disability of variable degree. Among the antiepileptic drugs, levetiracetam has a unique mechanism of action binding SV2A, a glycoprotein of the...

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Source

Identifiers

PMID: 26212315
DOI: 10.1016/j.braindev.2015.07.002

Genes

STXBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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