A common variant in ERBB4 regulates GABA concentrations in human cerebrospinal fluid.

doi:10.1038/npp.2012.57

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Article

A common variant in ERBB4 regulates GABA concentrations in human cerebrospinal fluid.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2012

Luykx Jurjen J, Vinkers Christiaan H, Bakker Steven C, Visser Wouter F, van Boxmeer Loes, Strengman Eric, van Eijk Kristel R, Lens Judith A, Borgdorff Paul, Keijzers Peter, Kappen Teus H, van Dongen Eric P A, Bruins Peter, Verhoeven Nanda M, de Koning Tom J, Kahn René S, Ophoff Roel A

Abstract excerpt

The neuregulin 1 (NRG1) receptor ErbB4 is involved in the development of cortical inhibitory GABAergic circuits and NRG1-ErbB4 signaling has been implicated in schizophrenia (SCZ). A magnetic resonance spectroscopy ((1)H-MRS) study has demonstrated that a single-nucleotide polymorphism in ERBB4, rs7598440, influences human cortical GABA concentrations. Other work has highlighted the significant impact of this...

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Identifiers

PMID: 22549119
DOI: 10.1038/npp.2012.57
PMCID: PMC3398713

Genes

ERBB4
NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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