Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2012

Doyle J R, Fortin J P, Beinborn M, Kopin A S

Abstract excerpt

The melanocortin 1 receptor (MC1R) is a highly polymorphic G protein-coupled receptor, which is known to modulate pigmentation and inflammation. In the current study, we investigated the pharmacological effects of select single-nucleotide polymorphisms (SNPs) (V60L, R163Q, and F196L). After transient expression of MC1Rs in human embryonic kidney 293 cells, basal and ligand-induced cAMP signaling and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-MSH
Share to Cell Line, Transformed
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imidazoles

Share to Inflammation

Share to Mitogen-Activated Protein Kinases

Share to NF-kappa B

Share to Receptor, Melanocortin, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 22547573
DOI: 10.1124/jpet.112.194548
PMCID: PMC3400803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways.PMID 22547573Read ↗

Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells.Semantic proximity Read ↗

Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles.Semantic proximity Read ↗

Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients.Semantic proximity Read ↗

Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways.Semantic proximity Read ↗

Genetic association and cellular function of MC1R variant alleles in human pigmentation.Semantic proximity Read ↗

Identification and functional characterization of natural human melanocortin 1 receptor mutant alleles in Pakistani population.Semantic proximity Read ↗

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.Semantic proximity Read ↗

MC4R Variants Modulate α-MSH and Setmelanotide Induced Cellular Signaling at Multiple LevelsSemantic proximity Read ↗

Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.Semantic proximity Read ↗

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands.Semantic proximity Read ↗

Human melanocytes expressing MC1R variant alleles show impaired activation of multiple signaling pathways.Semantic proximity Read ↗

MC1R Functions, Expression, and Implications for Targeted Therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.