Article
Human melanocytes expressing MC1R variant alleles show impaired activation of multiple signaling pathways.
Peptides - 1 Dec 2007
Newton Richard A, Roberts Donald W, Leonard J Helen, Sturm Richard A
Abstract excerpt
Variant alleles of the human MC1R gene are strongly associated with red hair color, fair skin and poor tanning ability (RHC-trait). Recently, we demonstrated that melanocytes harboring RHC-associated alleles have markedly reduced surface expression and/or impaired G-protein coupling of the corresponding receptor protein. The consequences of such a deficit on MC1R-mediated signaling pathways have now been...
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