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Article

Identification of NOG as a Specific Breast Cancer Bone Metastasis-supporting Gene

1 May 2012

Abstract excerpt

Metastasis requires numerous biological functions that jointly provide tumor cells from a primary site to seed and colonize a distant organ. Some of these activities are selected for in the primary site, whereas others are acquired at the metastatic niche. We provide molecular evidence showing that the BMP inhibitor, NOG, provides metastatic breast cancer cells with the ability to colonize the bone. NOG...

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PMID: 22547073
DOI: 10.1074/jbc.m112.355834

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