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Article

Role of squalene synthase in prostate cancer risk and the biological aggressiveness of human prostate cancer.

Prostate cancer and prostatic diseases - 1 Dec 2012

Fukuma Y, Matsui H, Koike H, Sekine Y, Shechter I, Ohtake N, Nakata S, Ito K, Suzuki K

Abstract excerpt

BACKGROUND: We previously conducted a genome-wide linkage analysis of Japanese nuclear families affected with prostate cancer and showed that the susceptibility to prostate cancer was closely linked to D8S550 at 8p23. The role of farnesyl diphosphate farnesyltransferase (FDFT1), which is located under the peak marker D8S550 at 8p23, and squalene synthase, the enzyme encoded by FDFT1, in prostate cancer was...

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Source

Identifiers

PMID: 22546838
DOI: 10.1038/pcan.2012.14

Genes

FDFT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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