A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.

doi:10.1016/j.ajhg.2012.04.001

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A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.

American journal of human genetics - 4 May 2012

Zhao Han, Xu Jianfeng, Zhang Haobo, Sun Jielin, Sun Yingpu, Wang Zhong, Liu Jiayin, Ding Qiang, Lu Shaoming, Shi Rong, You Li, Qin Yingying, Zhao Xiaoming, Lin Xiaoling, Li Xiao, Feng Junjie, Wang Li, Trent Jeffrey M, Xu Chengyan, Gao Ying, Zhang Bo, Gao Xuan, Hu Jingmei, Chen Hong, Li Guangyu, Zhao Junzhao, Zou Shuhua, Jiang Hong, Hao Cuifang, Zhao Yueran, Ma Jinglong, Zheng S Lilly, Chen Zi-Jiang

Abstract excerpt

A genome-wide association study of Han Chinese subjects was conducted to identify genetic susceptibility loci for nonobstructive azoospermia (NOA). In the discovery stage, 802 azoospermia cases and 1,863 controls were screened for genetic variants in the genome. Promising SNPs were subsequently confirmed in two independent sets of subjects: 818 azoospermia cases and 1,755 controls from northern China, and 606...

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PMID: 22541561
DOI: 10.1016/j.ajhg.2012.04.001
PMCID: PMC3376492

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