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Article

Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome.

Experimental neurology - 1 May 2016

Olmos-Serrano J Luis, Tyler William A, Cabral Howard J, Haydar Tarik F

Abstract excerpt

Mouse models have provided insights into adult changes in learning and memory in Down syndrome, but an in-depth assessment of how these abnormalities develop over time has never been conducted. To address this shortcoming, we conducted a longitudinal behavioral study from birth until late adulthood in the Ts65Dn mouse model to measure the emergence and continuity of learning and memory deficits in individuals...

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Identifiers

PMID: 26854932
DOI: 10.1016/j.expneurol.2016.02.005
PMCID: PMC5716476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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