Article
[DNA mutations associated to rifampicin or isoniazid resistance in M. tuberculosis clinical isolates from Sonora, Mexico].
Salud publica de Mexico - 1 Jan 2000
Bolado-Martínez Enrique, Pérez-Mendoza Ansix, Alegría-Morquecho Francisco Monserrat, Candia-Plata María del Carmen, Aguayo-Verdugo María del Rosario, Alvarez-Hernández Gerardo
Abstract excerpt
OBJECTIVE: To perform the analysis of specific regions of the major genes associated with resistance to isoniazid or rifampin. MATERIALS AND METHODS: Twenty two M. tuberculosis strains, isolated from human samples obtained in Sonora, Mexico. Specific primers for hotspots of the rpoB, katG, inhA genes and the ahpC-oxyR intergenic region were used. The purified PCR products were sequenced. RESULTS: Mutations in the...
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