Article
[Mutations linked with antimicrobial resistance in Mycobacterium tuberculosis isolated from tuberculosis patients in the Samara region].
Zhurnal mikrobiologii, epidemiologii i immunobiologii - 1 Jan 2000
Nikolaevskiĭ V V, Drobniewski F A, Brown T J, Balabanova Ia M, Ruddy M, Fedorin I M, Bazhora Iu I
Abstract excerpt
A total of 234 M. tuberculosis isolates were used to demonstrate the leading role of mutations in, respectively, codon 531 of gene rpoB (90.0%) and codon 315 of gene katG (92.9%), in the development of resistance to rifampicin and isoniazid by the methods of reverse hybridization with oligonucleotide probes and the sequencing of gene stretches. The levels of primary resistance of M. tuberculosis to rifampicin,...
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