Determination of carrier status in Duchenne and Becker muscular dystrophies by quantitative polymerase chain reaction and allele-specific oligonucleotides.

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Article

Determination of carrier status in Duchenne and Becker muscular dystrophies by quantitative polymerase chain reaction and allele-specific oligonucleotides.

Clinical chemistry - 1 Dec 1990

Prior T W, Papp A C, Snyder P J, Highsmith W E, Friedman K J, Perry T R, Silverman L M, Mendell J R

Abstract excerpt

Detection of carriers of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), in the deletion cases, involves calculating gene dosage from Southern blots. We show that the analysis of dosage can also be made from the polymerase chain reaction (PCR) with use of allele-specific ol...

Topics

Alleles
Exons
Genetic Carrier Screening
Humans
Muscular Dystrophies
Nucleic Acid Amplification Techniques
Polymerase Chain Reaction

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Open in PubMed

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PMID: 2253356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2253356-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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