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Article

Poliovirus trafficking toward central nervous system via human poliovirus receptor-dependent and -independent pathway

1 Jan 2012

Abstract excerpt

In humans, paralytic poliomyelitis results from the invasion of the central nervous system (CNS) by circulating poliovirus (PV) via the blood-brain barrier (BBB). After the virus enters the CNS, it replicates in neurons, especially in motor neurons, inducing the cell death that causes paralytic poliomyelitis. Along with this route of dissemination, neural pathway has been reported in humans, monkeys, and...

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PMID: 22529845
DOI: 10.3389/fmicb.2012.00147

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