Innate host barriers to viral trafficking and population diversity: lessons learned from poliovirus.

Abstract excerpt

Poliovirus is an error-prone enteric virus spread by the fecal-oral route and rarely invades the central nervous system (CNS). However, in the rare instances when poliovirus invades the CNS, the resulting damage to motor neurons is striking and often permanent. In the prevaccine era, it is likely that most individuals within an epidemic community were infected; however, only 0.5% of infected individuals developed...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Central Nervous System
• Share to Gastrointestinal Tract
• Share to Host-Pathogen Interactions