Article
Genetic variants in interleukin-2 and risk of lymphoma among children in Korea.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012
Song Nan, Han Sohee, Lee Kyoung-Mu, Choi Ji-Yeob, Park Sue K, Jeon Sujee, Lee Yunhee, Ahn Hyo Seop, Shin Hee Young, Kang Hyoung Jin, Koo Hong Hoe, Seo Jong Jin, Choi Ji Eun, Kang Daehee
Abstract excerpt
To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma (P(trend)<0.05) in six genes (IL1RN, IL2, IL12RB1,...
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