Article
EGFR somatic mutations in lung tumors: radon exposure and passive smoking in former- and never-smoking U.S. women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2012
Taga Masataka, Mechanic Leah E, Hagiwara Nobutoshi, Vähäkangas Kirsi H, Bennett William P, Alavanja Michael C R, Welsh Judith A, Khan Mohammed A, Lee Adam, Diasio Robert, Edell Eric, Bungum Aaron, Jang Jin Sung, Yang Ping, Jen Jin, Harris Curtis C
Abstract excerpt
BACKGROUND: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis when treated with EGFR inhibitors. We hypothesized that EGFR mutations may be related to residential radon or passive tobacco smoke. METHODS: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri...
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