Article
Low rates of synonymous mutations in sequences of Mycobacterium tuberculosis GyrA and KatG genes.
Tuberculosis (Edinburgh, Scotland) - 1 Jul 2012
Khrustalev Vladislav Victorovich, Arjomandzadegan Mohammad, Barkovsky Eugene Victorovich, Titov Leonid Petrovich
Abstract excerpt
Partial sequences of KatG and GyrA genes have been obtained from multi and extensively drug-resistant (MDR and XDR) clinical isolates of Mycobacterium tuberculosis. Nonsynonymous (DN) and synonymous (DS) distances between those sequences have been calculated by Kumar method. Results revealed that DN is significantly higher than DS between some pairs of partial GyrA sequences. We found out that DN is higher than...
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