Article
Mesenchymal stem cells reduce the genotoxic effect of lead acetate in the testis of male rats and induce testicular cellular proliferation indicated by 16S rRNA sequence, increase the proliferation marker Ki-67 and a reduction in the apoptosis marker caspase-3.
Biological research - 27 May 2025
Allam Mohamed, Amin Yahia A, Fouad Samer S, Ali Rana A, Fawy Mariam A, Ahmed Maha Abd-El Baki, Toghan Rana, Ali Lobna A
Abstract excerpt
BACKGROUND: Lead is a ubiquitous environmental and industrial pollutant with worldwide health problems. Lead acetate toxicity induces both genotoxic effects and apoptosis. The present study aimed to investigate the usage of mesenchymal stem cells (MSCs) in the treatment of the genotoxic effect of lead acetate (LA) in the testis and its effect on the expression of the apoptosis marker caspase-3 and the...
Read the complete abstract on PubMedTopics
- Mesenchymal Stem Cells
- Male
- Animals
- Rats
- Rats, Wistar