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Article

Genetic polymorphisms of the adenosine triphosphate-binding cassette transporters (ABCG2, ABCB1) and gefitinib toxicity.

Nagoya journal of medical science - 1 Feb 2012

Tamura Mariko, Kondo Masashi, Horio Mihoko, Ando Maki, Saito Hiroshi, Yamamoto Masashi, Horio Yoshitsugu, Hasegawa Yoshinori

Abstract excerpt

The purpose of this study is to investigate associations between allelic variations of ABCG2 and ABCB1 with skin toxicity, diarrhea, liver injury and interstitial lung disease (ILD) in gefitinib-treated patients. A prospective clinical study of 83 Japanese patients with non-small-cell lung cancer was performed. Polymorphic loci in ABCG2 and ABCB1 were genotyped, and their effects on gefitinib toxicities were...

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Identifiers

PMID: 22515119
PMCID: PMC4831258

Genes

ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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